+Apply search filters

Cancer Type
—

Systemic Anti-Cancer Therapy Regimen Library

Home > LEU ALL precursor B-cell BCR-ABL1+ - modified AALL1131 with imatinib > LEU - mAALL1131 with imatinib Maintenance [CNS1 and 2]

This regimen is a component of LEU ALL precursor B-cell BCR-ABL1+ - modified AALL1131 with imatinib

mAALL1131 with imatinib - Maintenance for CNS 1/2+ (LEU ALL precursor B-cell BCR-ABL1+ - modified AALL1131 with imatinib)

Treatment Overview

Use Maintenance regimen specific for CNS status of patient.

The intrathecal therapy in this Maintenance regimen is intended for patients with CNS1+ or 2+ disease, for those who did not receive CNS radiation.

Not to be used for transplant patients.

Starts on day 57 of Interim maintenance 2 or on count recovery, whichever occurs later.

Frequency: 84 days, or on count recovery.

Count recovery is defined as:

Neutrophils greater than 0.75 x 10⁹/L, and
Platelets greater than 75 x 10⁹/L.

Total treatment time is 2 years from the start of Interim maintenance 1. Therapy may be stopped on anniversary date if the 5-day prEDNISone is completed for the cycle.

Cycles 1 to 2 - 84 days

Cycle length:

imatinib: Take continuously during treatment, dose reduction may be required based on individual patient tolerability.

Oral metHOTREXATe:

Weekly dose is omitted on day 1 and 29 when intrathecal metHOTREXATe is given.
See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.

mercaptOPURine:

See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.
Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Intrathecal metHOTREXATe:

Scheduled day 1 and 29 of the first 2 cycles of Maintenance for CNS 1 and 2 disease, for those who did not receive CNS radiation.
For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Cycles 3 to 7 - 84 days

Cycle length:

imatinib: Continue treatment indefinitely, dose reduction may be required based on individual patient tolerability.

Oral metHOTREXATe:

Weekly dose is omitted on day 1 when intrathecal metHOTREXATe is given.
See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.

mercaptOPURine:

See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.
Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Cycle details

Cycles 1 to 2 - 84 days

Medication	Dose	Route	Days	Max Duration
imatinib *	400 mg Twice daily	oral administration	1 to 84
metHOTREXATe *	20 mg/m² Once a week	oral administration	8, 15, 22, 36, 43, 50, 57, 64, 71, 78
mercaptOPURine	75 mg/m² Once daily	oral administration	1 to 84
vinCRISTine *	1.5 mg/m² Cap dose per administration at: 2 mg	intravenous	1	10 minutes
prEDNISone	20 mg/m² Twice daily	oral administration	1 to 5
metHOTREXATe *	15 mg	intrathecal injection	1, 29

imatinib: Take continuously during treatment, dose reduction may be required based on individual patient tolerability.

Oral metHOTREXATe:

Weekly dose is omitted on day 1 and 29 when intrathecal metHOTREXATe is given.
See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.

mercaptOPURine:

See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.
Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Intrathecal metHOTREXATe:

Scheduled day 1 and 29 of the first 2 cycles of Maintenance for CNS 1 and 2 disease, for those who did not receive CNS radiation.
For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Cycles 3 to 7 - 84 days

Medication	Dose	Route	Days	Max Duration
imatinib *	400 mg Twice daily	oral administration	1 to 84
metHOTREXATe *	20 mg/m² Once a week	oral administration	8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78
mercaptOPURine	75 mg/m² Once daily	oral administration	1 to 84
vinCRISTine *	1.5 mg/m² Cap dose per administration at: 2 mg	intravenous	1	10 minutes
prEDNISone	20 mg/m² Twice daily	oral administration	1 to 5
metHOTREXATe *	15 mg	intrathecal injection	1

imatinib: Continue treatment indefinitely, dose reduction may be required based on individual patient tolerability.

Oral metHOTREXATe:

Weekly dose is omitted on day 1 when intrathecal metHOTREXATe is given.
See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.

mercaptOPURine:

See COG protocol for dose adjustments based on neutrophil and platelet counts during Maintenance.
Consider thiopurine methyltransferase (TPMT) testing and NUDT15 screening for specific patients.

Intrathecal metHOTREXATe: For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Full details

Cycles 1 to 2 - 84 days

Day: 1

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
vinCRISTine *	1.5 mg/m² Cap dose per administration at: 2 mg	intravenous	10 minutes	Instructions: Diluted in a minibag. FOR INTRAVENOUS USE ONLY – fatal if given by any other routes. Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration.
prEDNISone	20 mg/m² Twice daily	oral administration		Instructions: Take with food.
metHOTREXATe *	15 mg	intrathecal injection		Instructions: Adhere to local institution policy for intrathecal administration. For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Day: 2

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 3

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 4

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 5

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 6

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 7

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 8

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 9

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 10

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 11

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 12

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 13

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 14

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 15

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 16

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 17

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 18

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 19

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 20

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 21

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 22

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 23

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 24

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 25

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 26

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 27

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 28

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 29

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
metHOTREXATe *	15 mg	intrathecal injection	Instructions: Adhere to local institution policy for intrathecal administration. For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Day: 30

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 31

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 32

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 33

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 34

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 35

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 36

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 37

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 38

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 39

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 40

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 41

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 42

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 43

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 44

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 45

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 46

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 47

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 48

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 49

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 50

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 51

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 52

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 53

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 54

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 55

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 56

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 57

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 58

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 59

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 60

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 61

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 62

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 63

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 64

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 65

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 66

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 67

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 68

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 69

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 70

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 71

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 72

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 73

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 74

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 75

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 76

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 77

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 78

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 79

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 80

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 81

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 82

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 83

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 84

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Cycles 3 to 7 - 84 days

Day: 1

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
vinCRISTine *	1.5 mg/m² Cap dose per administration at: 2 mg	intravenous	10 minutes	Instructions: Diluted in a minibag. FOR INTRAVENOUS USE ONLY – fatal if given by any other routes. Warning vesicant—ensure vein is patent prior to administration, administer vesicant as per institutional policy and monitor for signs of extravasation throughout administration.
prEDNISone	20 mg/m² Twice daily	oral administration		Instructions: Take with food.
metHOTREXATe *	15 mg	intrathecal injection		Instructions: Adhere to local institution policy for intrathecal administration. For Ommaya reservoir reduce dose to 6 mg intraventricularly.

Day: 2

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 3

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 4

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 5

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.
prEDNISone	20 mg/m² Twice daily	oral administration	Instructions: Take with food.

Day: 6

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 7

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 8

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 9

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 10

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 11

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 12

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 13

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 14

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 15

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 16

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 17

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 18

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 19

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 20

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 21

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 22

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 23

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 24

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 25

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 26

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 27

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 28

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 29

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 30

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 31

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 32

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 33

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 34

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 35

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 36

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 37

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 38

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 39

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 40

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 41

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 42

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 43

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 44

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 45

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 46

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 47

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 48

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 49

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 50

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 51

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 52

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 53

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 54

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 55

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 56

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 57

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 58

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 59

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 60

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 61

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 62

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 63

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 64

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 65

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 66

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 67

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 68

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 69

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 70

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 71

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 72

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 73

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 74

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 75

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 76

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 77

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 78

Medication	Dose	Route	Details
imatinib *	400 mg Twice daily	oral administration	Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
metHOTREXATe *	20 mg/m² Once a week	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Protect yourself from too much natural or artificial sunlight while being treated with this medicine. Round dose to closest multiple of 2.5 mg tablets.
mercaptOPURine	75 mg/m² Once daily	oral administration	Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 79

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 80

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 81

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 82

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 83

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Day: 84

Medication	Dose	Route	Max duration	Details
imatinib *	400 mg Twice daily	oral administration		Instructions: Take each dose with food and a large glass of water. Dose reduction may be required based on patient tolerability.
mercaptOPURine	75 mg/m² Once daily	oral administration		Instructions: See COG protocol for dose adjustments based on neutrophil and platelet counts. Take each dose on an empty stomach – one hour before OR three hours after food or milk. Round dose to closest multiple of 25 mg.

Supportive Care Factors

Factor	Value
Antiviral prophylaxis for herpes virus:	Routine antiviral prophylaxis recommended
Constipation risk:	Variable
Diarrhoea risk:	Variable
Emetogenicity:	Minimal to low
Gastroprotection:	Gastroprotection is recommended
Pneumocystis jirovecii pneumonia (PJP) prophylaxis:	Routine antibiotic prophylaxis recommended

Antiviral prophylaxis for hepatitis B virus: Guidance is limited to high-risk anti-cancer medicines. Clinicians will need to assess individual patient risk for other anti-cancer medicines.

Diarrhoea/Constipation risk: imatinib may cause diarrhoea and vinCRISTine may cause constipation. Monitor gastrointestinal symptoms.

Emetogenicity: imatinib: MINIMAL to LOW ≤400 mg; MEDIUM to HIGH >400 mg; however, based on New Zealand clinical experience emetogenicity for imatinib doses greater than 400 mg may also only be Minimal to low.

Gastroprotection: Agents are only intended for short term use while patient is receiving corticosteroid treatment doses.

References

No references

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.

Cancer Type —

Systemic Anti-Cancer Therapy Regimen Library

mAALL1131 with imatinib - Maintenance for CNS 1/2+ (LEU ALL precursor B-cell BCR-ABL1+ - modified AALL1131 with imatinib)

Treatment Overview

Cycles 1 to 2 - 84 days

Cycles 3 to 7 - 84 days

Cycle details

Cycles 1 to 2 - 84 days

Cycles 3 to 7 - 84 days

Full details

Cycles 1 to 2 - 84 days

Day: 1

Day: 2

Day: 3

Day: 4

Day: 5

Day: 6

Day: 7

Day: 8

Day: 9

Day: 10

Day: 11

Day: 12

Day: 13

Day: 14

Day: 15

Day: 16

Day: 17

Day: 18

Day: 19

Day: 20

Day: 21

Day: 22

Day: 23

Day: 24

Day: 25

Day: 26

Day: 27

Day: 28

Day: 29

Day: 30

Day: 31

Day: 32

Day: 33

Day: 34

Day: 35

Day: 36

Day: 37

Day: 38

Day: 39

Day: 40

Day: 41

Day: 42

Day: 43

Day: 44

Day: 45

Day: 46

Day: 47

Day: 48

Day: 49

Day: 50

Day: 51

Day: 52

Day: 53

Day: 54

Day: 55

Day: 56

Day: 57

Day: 58

Day: 59

Day: 60

Day: 61

Day: 62

Day: 63

Day: 64

Day: 65

Day: 66

Day: 67

Day: 68

Day: 69

Cancer Type
—